The pouch should only be opened immediately prior to use. If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately. A cat in the 3× group exhibited depression, dehydration, a hunched position, and inability to stand 22 days after dosing. Peak moxidectin concentrations are achieved between 1 and 5 days following topical administration and the elimination half-life ranges between 20 and 30 days. One cat exhibited transient lacrimation from one eye during the first 15 minutes after dosing. The safety of Bravecto Plus has not been established in breeding, pregnant, and lactating cats. Additional information can be found at www.bravecto.com. Bravecto Plus kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick) and Dermacentor variabilis (American dog tick)] for 2 months in cats and kittens 6 months of age and older and weighing 2.6 lb or greater. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis), gross pathology, histopathology, or organ weights. Margin of Safety Study: In a margin of safety study, Bravecto Plus was administered topically to 9- to 13-week-old (mean age 12 weeks) kittens at 1×, 3×, and 5× the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg at three, 8-week intervals (10 kittens per group). Copy the URL below and paste it into your RSS Reader application. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis), gross pathology, histopathology, or organ weights. However, for indoor cats, Bravecto’s treatment is still a three-month preventative. Bravecto for Cats; Bravecto for Cats. Updated In cats, Bravecto ® Spot-On provides 3 months of protection against fleas and ticks. Bravecto Plus is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment of infections with intestinal roundworm (Toxocara cati; 4th stage larvae, immature adults and adults) and hookworm (Ancylostoma tubaeforme; 4th stage larvae, immature adults and adults). The effectiveness of Bravecto Plus to prevent heartworm disease after bathing or water immersion has not been evaluated. Avoid contact with skin and eyes. Part the hair and apply to the skin on the back of the head, as per the diagram. After applying Bravecto for Cats, the medication quickly reaches tissue fluids under your cat's skin. The product is highly flammable. Keep away from heat, sparks, open flame or other sources of ignition. The chemical name of fluralaner is (±)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2- trifluoroethylamino) ethyl]benzamide. G4408 (Act 36/1947) For Small Cats . View NDC Code(s)NEW! Inactive ingredients: dimethylacetamide, glycofurol, diethyltoluamide, acetone, butylhydroxytoluene. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Treated kittens had reduced food consumption on the day of treatment. Bravecto for Cats is available in three strengths for use in cats (112.5 mg, 250 mg, and 500 mg fluralaner per tube). It binds to gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels of the nerves and muscles of the parasite resulting in hyperpolarization, paralysis and death. Bravecto Plus Spot-On is for cats with, or at risk from, mixed parasitic infections by ticks and fleas, gastrointestinal nematodes or heartworm. Margin of Safety Study: In a margin of safety study, Bravecto Plus was administered topically to 9- to 13-week-old (mean age 12 weeks) kittens at 1X, 3X, and 5X the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg at three, 8-week intervals (10 kittens per group). When fleas and ticks bite, they ingest the solution and die within 8 hours. The safety of Bravecto Plus has not been established in breeding, pregnant, and lactating cats. Oral Safety Studies: In an oral safety study, one dose of Bravecto Plus was administered orally to 4- to 9-month-old kittens at the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg. In well-controlled laboratory studies, Bravecto Plus was effective against naturally and experimentally induced adult and experimentally induced 4th stage larval and immature adult Toxocara cati and Ancylostoma tubaeforme infections in cats. If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately. Percentage of Cats with Adverse Reactions (AR) in the Field Study, Safety in cats infected with adult heartworm (Dirofilaria immitis), All Drug 0061-5997-01, Bravecto Plus kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick) and Dermacentor variabilis (American dog tick)] for 2 months in cats and kittens 6 months of age and older and weighing 2.6 lb or greater. There are no known contraindications for the use of the product. Step 1: Immediately before use, open the pouch and remove the tube. In well-controlled laboratory studies, Bravecto Plus was effective against naturally and experimentally induced adult and experimentally induced 4th stage larval and immature adult Toxocara cati and Ancylostoma tubaeforme infections in cats. Advantages NEW BRAVECTO® PLUS (fluralaner and moxidectin topical solution) for Cats is the solution for fleas, ticks, heartworm and intestinal parasites in ONE easy, 2-month topical. Do not store above 77°F (25°C). Set Descending Direction. Peak moxidectin concentrations are achieved between 1 and 5 days following topical administration and the elimination half-life ranges between 20 and 30 days. In a well-controlled laboratory study, Bravecto Plus killed 100% of fleas within 12 hours after treatment and reduced the numbers of live fleas on cats by >99% within 12 hours after treatment or infestation for 2 months. Five of six treated kittens experienced hypersalivation. In well-controlled laboratory studies, Bravecto Plus demonstrated ≥ 98.1% effectiveness against Ixodes scapularis 48 hours after treatment or infestation for 2 months. If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot. Moxidectin is for systemic use and is a semisynthetic derivative of nemadectin, belonging to the milbemycin group of macrocyclic lactones. In well-controlled laboratory effectiveness studies, the following adverse reactions were seen after application of Bravecto Plus: pyrexia, tachypnea, mydriasis, pruritus, scabbing, and bloody stool. There were no clinically-relevant, treatment-related effects on body weights, clinical pathology (hematology, clinical chemistry, and coagulation profile), gross pathology or histopathology. Self-limiting hypersalivation due to grooming was observed on the day of treatment in both treatment groups (6/8 cats in the 1× group and 7/8 cats in the 3× group). Additional signs, including blurred vision and disorientation, occurred after taking an antihistamine. Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. 3 doses of BRAVECTO® per pet, get a rebate of $20; 4 doses of BRAVECTO® per pet, get a rebate of $30. Part the hair and apply directly to the skin. Heartworms were found in the epidural space in the second cat of the 1X group and the cat in the 3X group. For topical use only. Avoid applying an excessive amount of solution that could cause some of the solution to run and drip off of the cat. For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. *ALT was greater than twice the upper reference range of 100 IU/L. Reg. Bravecto Plus is available in three tube sizes to treat cats ranging in weight from 2.6 lb - 27.5 lb (1.2 kg to 12.5 kg). In foreign market experience reports for Bravecto Plus, one veterinarian experienced tingling and numbness of the fingers, hand, and arm, and swelling of the hand and arm after getting Bravecto Plus on her fingers. Two untreated cats were found dead prior to dosing. It treats and prevents ticks, fleas, heartworms, and several kinds of worms. Cosmetic changes at the application site included matting/clumping/spiking of hair, wetness, or a greasy appearance. Do not use directly on any skin lesions. This solution seeps into the tissues located beneath the skin, and when fleas and ticks bite, they ingest the solution and die within 8 hours. Apply at the base of the skull, to ensure wet product can't be licked. is a systemic insecticide and Avoid oral ingestion. In a European field study for fluralaner topical solution for cats, there were three reports of facial dermatitis in humans after close contact with the application site which occurred within 4 days of application. Avoid applying an excessive amount of solution that could cause some of the solution to run and drip off of the cat. Two untreated cats were found dead prior to dosing. The cap should be rotated clockwise or counter clockwise one full turn. When fleas and ticks feed on your cat, they ingest Bravecto for Cats and die. Files, Presentations In a pilot oral safety study, adult cats orally administered 0.5× or 1× the maximum labeled dose of Bravecto Plus had foaming hypersalivation for up to five minutes and reduced food consumption on the day of dosing. Step 1: Immediately before use, open the pouch and remove the tube. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, or clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis). How to use Bravecto Spot-on for Cats Ensure the animal's back is horizontal. Part the fur at the administration site. Each tube is packaged individually in a pouch. The cats in the control group (0×) received mineral oil topically. The effectiveness of Bravecto Plus to prevent heartworm disease after bathing or water immersion has not been evaluated. Field Safety Study: In a well-controlled field study, Bravecto Plus was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics and steroids. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Select one or more newsletters to continue. Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. Normal forms opened the packaging I split some on my hands advice, diagnosis or treatment for. % effectiveness against Ixodes scapularis 48 hours after treatment or infestation for 2 months your own personal medication.. 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